Dengue vaccines have been demonstrated to be quite beneficial, particularly in high-transmission areas, with the initial risk decreasing over time.

Dengue vaccine is an oral vaccination that protects against dengue fever, a viral infection caused by a strain of yellow fever virus. Dengue vaccines were first developed in the 1920s in order to establish protection against the four known dengue serogroup viruses. Lederatin produced a prototype dengue vaccine, which was later approved by the US Food and Drug Administration (FDA). However, there are still concerns about the vaccine's use, and certain governments are opposed to it. This vaccine has been associated to numerous health issues, particularly in children. It can also result in catastrophic birth abnormalities and neurological problems.

The dengue virus is a member of the Fila virus family, which is a virus that affects insects. It was first detected and identified in wild Chinese mice in China. The dengue virus was isolated and examined further as a result of these experiments. These mice are thought to have contracted the virus as a result of bathing in polluted water. The dengue virus strain quickly spread to other mouse strains, and the number of reported cases of the disease skyrocketed. The exact causes of the virus are still being investigated, especially because dengue infection can be spread from one person to another even after the symptoms have passed. However, the development of the dengue vaccines have paved the way to reducing the dengue outbreak and preventing its transmission to future generations. Hence, the vaccines can also minimize the number of reported cases in the future. In fact, the vaccines have been given the green light by the U.S. FDA; there have been no reports of adverse reactions associated with its use.

One of the primary drawbacks of the dengue vaccination for children is that it only protects them against the disease strains that have been found thus far. This means that the disease has the potential to reappear, especially because there is currently no preventative treatment for dengue fever. Cases of children acquiring encephalopathy, a disorder characterised by mental impairment and cerebellar hypoplasia, have been reported. The Centers for Disease Control and Prevention (CDC) is still working to identify all strains of the dengue virus and prevent emerging viruses from causing serious health concerns.