Tuesday, 29 June 2021

Cellulose Derivative; Widely Used as Excipient in Cosmetic & Pharmaceutical Industries

 

Cellulose derivatives


Cellulose derivatives such as hydroxypropyl cellulose, carboxymethyl cellulose (CMC), and methylcellulose are widely used to produce films due to their suitable properties. Moreover, cellulose derivative has strong shape-preserving capacity and high viscosity, which makes it an ideal choice for the food and beverage industry. Water retention, film formation, binding, thickening, and high lubricity are some of the characteristics of cellulose derivatives. This has led to increase in consumption of cellulose derivatives in various end-use industries, such as paper, personal care, mining, and construction, among others.

In the pharmaceuticals industry, cellulose derivatives are also used in mucoadhesive and bio-adhesive drug delivery systems. Moreover, cellulose derivatives are used in enteric coated solid dosage forms, compressibility enhancers, extended release formulations, osmotic drug delivery systems, and various other applications. They are most commonly used to modify the release of drugs in tablet and capsule formulations for the purpose of tablet binding, adhesion, water retention, film formation, and thickening as suspending and emulsifying agents.
Furthermore, cellulose derivatives provide wide-ranging capabilities, such as stability, anti-inflammatory, anti-scalp, anti-fungal, anti-bacterial, emulsification, reversible gelation, etc. A material known as non-rigid polysaccharides is the major ingredient of cellulose derivatives that are highly effective in curing a wide variety of skin diseases such as psoriasis, eczema, wounds, acne, burns, rashes, itching, scars, dry skin, scaling, inflammation, dermatitis, redness, inflammation, thickened skin, bacterial and fungal infections, etc.
Cellulose derivatives refer to any polymer which is derived from cellulose. Cellulose is a fibrous natural substance found in most plant material as well as some animals and manmade products. The demand for cellulose derivative is primarily driven by the increasing demand from the pharmaceutical, cosmetic, and personal care industries for hygienic, cost-effective, and skin-friendly products that can replace costly ingredients. Cellulose derivatives are often used in cosmetics industry as rheology modifiers for formulating a large variety of products.
These components are highly demanded in the medical world. In the pharmaceutical industry, cellulose derivatives extensively used as ingredients in various medicines. Pharmaceutical industries use these products in producing capsules, pills, tablets, ointments, creams, gels, solutions, inhalable forms, etc. It is also used to produce antimicrobial drugs. Cellulose is an excellent material for manufacturing beads, granules, and powders. Thus, it is used in making powders for various industries, such as food, cosmetic, medicine, and cosmetic industry.
Methylcellulose (or methyl cellulose) is a chemical compound derived from cellulose. It is used as a thickener and emulsifier in various cosmetic and food products and also as a bulk-forming laxative. The most important derivatives of cellulosic ethers includes hydroxypropyl methyl propyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, ethyl cellulose, sodium carboxymethyl cellulose, and methyl hydroxyethyl cellulose. Among all derivatives, sodium carboxymethyl cellulose widely used in pharmaceutical, food & beverage, health and personal care products, detergents, paper making, agriculture/animal feed/poultry, oil drilling, textile, and mining flotation, because of its significant properties.

Due to their unique properties, cellulose derivatives are major components in the cosmetics manufacturing. They may act as a thickener, film formers, emulsifier, dispersion, humectants, stabilizer, gelatinizers, binder, and as well as to improve viscosity of the products. Thus, they are used in most cosmetic products such as lip-liner, eye-liner, mascara, foundation, face wash, facial masks, toothpaste, foaming agent, and shampoo, for quality enhancement.

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