Precision medicine is based on knowing the effects of certain gene mutations (changes). The goal of precision medicine is to give a treatment that can target a gene mutation, without causing too many side effects. In precision medicine, B-Cell Maturation Antigen (BCMA) is a novel treatment target for multiple myeloma (MM) due to its highly selective expression in malignant plasma cells (PCs).
Multiple myeloma is a cancer that forms in a type of white blood cell called a plasma cell. The majority of people diagnosed with MM have been treated with standard treatment modalities, with positive results. Unfortunately, MM is a chronic condition that requires multiple drugs and multiple surgery procedures to control and slow its progression. Also, patients frequently experience multiple side effects from conventional therapies, further complicating the disease's impact on quality of life. The search for an effective and safe therapy for this difficult-to-treat condition has led to the development of B-Cell Maturation Antigen (BCMA) targeted therapies. This targeted delivery system provides a novel method for controlling the growth of malignant plasma cells and may also be effective in preventing the disease's progression.
Since the discovery of the biological role of BCMA in the development of multiple myeloma, several potential drug targets have been identified. In December 2019, The Janssen Pharmaceutical Companies of Johnson & Johnson received the U.S. Food and Drug Administration (FDA)’s Breakthrough Therapy Designation for JNJ-68284528 (JNJ-4528), an investigational BCMA-directed chimeric antigen receptor T cell (CAR-T) therapy in previously treated patients with multiple myeloma.
Clinical trials are currently underway for new B-Cell Maturation Antigen (BCMA) targeted therapies that have been shown to improve the prognosis of patients with myeloma, a cancer that originates from the blood and lymph systems. Myeloma is one of the most commonly diagnosed cancers among adults, yet its true prognosis depends greatly on the type of cancer and on the extent to which it has spread to the various organs of the body.
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